Involvement of the STING signaling in COVID-19Review Published on 2022-12-082023-07-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] COVID-19 IFNs SARS-CoV-2 STING vaccine. [DOI] 10.3389/fimmu.2022.1006395 PMC 바로가기 [Article Type] Review
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Identification of serum metabolites enhancing inflammatory responses in COVID-19Article Published on 2022-10-012022-11-15 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype [DOI] 10.1007/s11427-021-2099-7 PMC 바로가기
Friend or foe: RIG- I like receptors and diseasesArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation anti-tumor immunity antibody Antiviral antiviral immune response Autoimmune diseases autoinflammatory disease Autoinflammatory diseases Bacterial infections cascade disease Diseases Friend genes encoding Guidance Host IFNs immunomodulatory therapy include involved malaria MDA5 mechanism mechanisms microRNA miRNAs Mutation polymorphism post-translational modification proinflammatory cytokines Proteins recent finding receptor Regulatory RIG-I RLR RLRs RLRs. RNA virus SARS-CoV-2 Signaling single-nucleotide SNPs transcriptional type I interferon [DOI] 10.1016/j.autrev.2022.103161 PMC 바로가기
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signalingFACT 소단위 SUPT16H는 BRD4와 연관되어 인터페론 신호 전달 억제에 기여합니다Article Published on 2022-08-262022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, [키워드] acetylated acetylation Activation Affect association BRD4 cause CBL0137 cells chromatin co-culture complex composed contribute demonstrated Depletion domain enzyme epithelial EZH2 gene transcription Genetic HDAC1 heterodimeric protein histone chaperone IFN IFN signaling IFNs infected cells Infection Influenza inhibit inhibitor interferon interferon signaling interferon-stimulated gene interferon-stimulated genes ISGs killing knockdown lysine mechanism Modification natural killer NK cells pharmacological promote promoter Protein protein stability regulate regulated reported RNAi SARS-CoV-2 shown Signaling SSRP1 subunit suppression SUPT16H Transcription treat viral infections virus-infected cell virus-infected cells viruses Zika [DOI] 10.1093/nar/gkac645 PMC 바로가기 [Article Type] Article
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translationSARS-CoV-2는 mRNA 번역의 NSP2 유도 억제를 통해 인터페론 생산을 손상시킵니다Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 4EHP Antiviral binding cellular cytokine Cytokines Depletion ENhance evade GIGYF2 IFN-β IFNB1 IFNs immunostimulatory impair inhibit innate immune response interact Interaction interferon interferons intrinsic mechanism mRNA mRNA translation mRNA translation. NSP2 Protein RNA viruses SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress target the SARS-CoV-2 the SARS-CoV-2 virus translation type I interferon type I interferons [DOI] 10.1073/pnas.2204539119 PMC 바로가기 [Article Type] Article
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins structural proteins. suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferon. interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literatureReview article Published on 2022-08-012022-10-05 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE addition affecting age article association CCR5 cellular protease Clinical outcome Comorbidities correlation COVID-19 COVID-19 severity Deletion evaluate expression finding Genetic Genetic predisposition genetic risk genetic susceptibility genetics help HLA haplotypes host genetics IFNs IFNλ immune system individual Mortality mutations polymorphism Polymorphisms Proteins reduced retrieved risk risk factor SARS-CoV-2 several gene severity severity of COVID-19 smoking susceptibility systematic review TLR TMPRSS2 TNF Treatment upregulation vaccination Variability with COVID-19 [DOI] 10.1016/j.gene.2022.146674 [Article Type] Review article